Article

Glutamatergic dysfunction precedes neuron loss in cerebral organoids with <i>MAPT</i> mutation

2021-02-03

Abstract excerpt

<h4>SUMMARY</h4> Frontotemporal dementia (FTD) due to MAPT mutation causes pathological accumulation of tau and glutamatergic cortical neuronal death by unknown mechanisms. We used human induced pluripotent stem cell (iPSC)-derived cerebral organoids expressing tau-V337M and isogenic corrected controls to discover early alterations due to the mutation that precede neurodegeneration. At 2 months, mutant organoids...

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Literature Corpus work: b5c63a85-a77b-5f86-b2ea-09528c63dfa4
DOI: 10.1101/2021.02.03.429623

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