Article
Human tau mutations in cerebral organoids induce a progressive dyshomeostasis of cholesterol.
Stem cell reports - 13 Sept 2022
Glasauer Stella M K, Goderie Susan K, Rauch Jennifer N, Guzman Elmer, Audouard Morgane, Bertucci Taylor, Joy Shona, Rommelfanger Emma, Luna Gabriel, Keane-Rivera Erica, Lotz Steven, Borden Susan, Armando Aaron M, Quehenberger Oswald, Temple Sally, Kosik Kenneth S
Abstract excerpt
Mutations in the MAPT gene that encodes tau lead to frontotemporal dementia (FTD) with pathology evident in both cerebral neurons and glia. Human cerebral organoids (hCOs) from individuals harboring pathogenic tau mutations can reveal the earliest downstream effects on molecular pathways within a developmental context, generating interacting neurons and glia. We found that in hCOs carrying the V337M and R406W tau...
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