Article

Epithelial-Intrinsic Alterations and Maladaptation to Luminal Metabolites Underlie Persistent Crohn’s Disease Pathogenesis

2026-08-04

Abstract excerpt

<h4>Summary</h4> In patients with Crohn’s disease, the noninflamed intestinal epithelium exhibits inflammation-like transcriptional signatures that persist even during clinical remission. However, it is unclear whether this signature is due to sustained environmental triggers or to the epithelium’s intrinsic immunological adaptions. To disentangle environmental and cell-intrinsic effects on disease signatures, we...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c24b2db6-5744-5e97-95d6-7456a64b3bdb
DOI: 10.64898/2026.07.29.741535

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epithelial-Intrinsic Alterations and Maladaptation to Luminal Metabolites Underlie Persistent Crohn’s Disease PathogenesisDOI 10.64898/2026.07.29.741535Read

A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized TherapeuticsSemantic proximity Read

A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.Semantic proximity Read

Assessing Cellular and Transcriptional diversity of IIeal Mucosa amongst Treatment Naïve and Treated Crohn’s diseaseSemantic proximity Read

Intestinal Stem and Progenitor Cells Exhibit Distinct Adaptive Responses to Inflammatory Stress in IBDSemantic proximity Read

Epithelia mediate inflammation with myeloid cells in Crohn’s disease patients under treatmentSemantic proximity Read

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read

Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac diseaseSemantic proximity Read

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn’s diseaseSemantic proximity Read

New Approach Methodologies in Crohn’s Disease Link Molecular Disease Subtypes to Clinical OutcomesSemantic proximity Read

A stromal-state dichotomy governs recalcitrance or remission in inflammatory bowel diseaseSemantic proximity Read

Ileal derived organoids from Crohn’s disease patients show unique transcriptomic and secretomic signaturesSemantic proximity Read

New approach methodologies in Crohn's disease link molecular disease subtypes to clinical outcomes.Semantic proximity Read