Article
New approach methodologies in Crohn's disease link molecular disease subtypes to clinical outcomes.
American journal of physiology. Gastrointestinal and liver physiology - 1 Mar 2026
Penrose Harrison M, Sinha Saptarshi, Tindle Courtney, Zablan Kameron, Le Helen N, Neill Jennifer, Ghosh Pradipta, Boland Brigid S
Abstract excerpt
Current clinical decision-making is hindered by the absence of predictive preclinical models that faithfully bridge molecular diversity to patient outcomes. Here, we apply the principle of abstraction-deriving essential features from human tissues to build next-generation new approach methodologies (NAMs) that transform patient-derived organoids (PDOs) into predictive vehicles for Crohn's disease (CD). From our...
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