Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.

Cell reports. Medicine - 15 Oct 2024

Tindle Courtney, Fonseca Ayden G, Taheri Sahar, Katkar Gajanan D, Lee Jasper, Maity Priti, Sayed Ibrahim M, Ibeawuchi Stella-Rita, Vidales Eleadah, Pranadinata Rama F, Fuller Mackenzie, Stec Dominik L, Anandachar Mahitha Shree, Perry Kevin, Le Helen N, Ear Jason, Boland Brigid S, Sandborn William J, Sahoo Debashis, Das Soumita, Ghosh Pradipta

Abstract excerpt

Crohn's disease (CD) is a complex and heterogeneous condition with no perfect preclinical model or cure. To address this, we explore adult stem cell-derived organoids that retain their tissue identity and disease-driving traits. We prospectively create a biobank of CD patient-derived organoid cultures (PDOs) from colonic biopsies of 53 subjects across all clinical subtypes and healthy subjects. Gene expression...

Topics

Join the communities discussing this publication.

Adult Stem Cells
Biological Specimen Banks
Colon
Crohn Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Precision Medicine

Source

Open in PubMed Open full text

Identifiers

PMID: 39332415
DOI: 10.1016/j.xcrm.2024.101748
PMCID: PMC11513829

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A living organoid biobank of patients with Crohn's disease reveals molecular subtypes for personalized therapeutics.PMID 39332415Read ↗

A Living Organoid Biobank of Crohn’s Disease Patients Reveals Molecular Subtypes for Personalized TherapeuticsSemantic proximity Read ↗

New approach methodologies in Crohn's disease link molecular disease subtypes to clinical outcomes.Semantic proximity Read ↗

New Approach Methodologies in Crohn’s Disease Link Molecular Disease Subtypes to Clinical OutcomesSemantic proximity Read ↗

Single-cell transcriptomics of rectal organoids from individuals with perianal fistulizing Crohn’s disease reveals patient-specific signaturesSemantic proximity Read ↗

Ileal derived organoids from Crohn’s disease patients show unique transcriptomic and secretomic signaturesSemantic proximity Read ↗

Epithelial-Intrinsic Alterations and Maladaptation to Luminal Metabolites Underlie Persistent Crohn’s Disease PathogenesisSemantic proximity Read ↗

Ileal Derived Organoids From Crohn’s Disease Patients Show Unique Transcriptomic and Secretomic SignaturesSemantic proximity Read ↗

The Promise of Patient-Derived Colon Organoids to Model Ulcerative ColitisSemantic proximity Read ↗

Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell typesSemantic proximity Read ↗

Single-Cell RNA Sequencing of Terminal Ileal Biopsies Identifies Signatures of Crohn’s Disease PathogenesisSemantic proximity Read ↗

Dictionary of human intestinal organoid responses to secreted niche factors at single cell resolutionSemantic proximity Read ↗

Bioengineered human colon organoids with in vivo-like cellular complexity and functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.