Article

Ileal derived organoids from Crohn’s disease patients show unique transcriptomic and secretomic signatures

2021-05-29

Abstract excerpt

<h4>Background</h4> We used patient derived organoids (PDOs) to study the epithelial-specific transcriptional and secretome signatures of the ileum during CD with varying phenotypes to screen for disease profiles and potential druggable targets. <h4>Methods</h4> RNA sequencing was performed on isolated intestinal crypts and 3-week-old PDOs derived from ileal biopsies of CD patients (n= 8 B1, inflammatory; n= 8 B2,...

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Literature Corpus work: 8f1619fd-a2f1-56b1-8755-e22985421fb5
DOI: 10.1101/2021.05.27.21257584

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