Article

New Approach Methodologies in Crohn’s Disease Link Molecular Disease Subtypes to Clinical Outcomes

2025-04-03

Abstract excerpt

<h4>ABSTRACT</h4> Current clinical decision-making is hindered by the absence of predictive preclinical models that faithfully bridge molecular diversity to patient outcomes. Here, we apply the principle of abstraction—deriving essential features from human tissues to build next-generation new approach methodologies ( NAMs ) that transform patient-derived organoids ( PDOs ) into predictive vehicles for Crohn’s...

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Literature Corpus work: d7d70d0b-3066-5b50-bdc4-11512d4b3875
DOI: 10.1101/2025.04.01.25325058

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