Article

An epigenetic basis for sustained inflammatory epithelial progenitor cell states in Crohn’s disease

2024-11-23

Abstract excerpt

<h4>SUMMARY</h4> Defining consequential differences in intestinal epithelial stem cells in healthy humans versus those with inflammatory bowel disease (Crohn’s disease and ulcerative colitis) is essential for the development of much needed therapies to restore the epithelial barrier and maintain its fidelity. Employing single cell transcriptomic/epigenomic approaches and colonoid models from children and adults w...

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Literature Corpus work: 8d41a2ba-caad-51b7-b986-e128a7ea5831
DOI: 10.1101/2024.11.22.622113

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