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Immune–epithelial–stromal networks define the cellular ecosystem of the small intestine in celiac disease

6 May 2025

Abstract excerpt

Abstract The immune–epithelial–stromal interactions underpinning intestinal damage in celiac disease (CD) are incompletely understood. To address this, we performed single-cell transcriptomics (RNA sequencing; 86,442 immune, parenchymal and epithelial cells; 35 participants) and spatial transcriptomics (20 participants) on CD intestinal biopsy samples. Here we show that in CD, epithelial populations shifted...

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PMID: 40328997
DOI: 10.1038/s41590-025-02146-2

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