Article

Antigen-specific humoral immune responses by CRISPR/Cas9-edited B cells

2019-01-26

Abstract excerpt

A small number of HIV-1 infected individuals develop broadly neutralizing-antibodies to the virus (bNAbs). These antibodies are protective against infection in animal models. However, they only emerge 1 - 3 years after infection, and show a number of highly unusual features including exceedingly high levels of somatic mutations. It is therefore not surprising that elicitation of protective immunity to HIV-1 has no...

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Literature Corpus work: c21bb5ca-2885-5ed2-b6fd-8629d7eef4a0
DOI: 10.1101/530832

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