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HIV-specific humoral immune responses by CRISPR/Cas9-edited B cells

11 Apr 2019

Abstract excerpt

A small number of HIV-1–infected individuals develop broadly neutralizing antibodies to the virus (bNAbs). These antibodies are protective against infection in animal models. However, they only emerge 1–3 yr after infection, and show a number of highly unusual features including exceedingly high levels of somatic mutations. It is therefore not surprising that elicitation of protective immunity to HIV-1 has not...

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PMID: 30975893
DOI: 10.1084/jem.20190287

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