Article

B Lymphocyte Protein Factories produced by Hematopoietic Stem Cell Gene Editing

2026-01-18

Abstract excerpt

Long-term in vivo production of therapeutic proteins and development of vaccines that elicit protective levels of broadly neutralizing antibodies (bNAbs) against major pathogens face challenges. Here we report on an alternative gene-editing approach using small numbers of hematopoietic stem and progenitor cells (HSPCs) to direct long-term, high-level expression of antibodies or cargo proteins. Edited B lymphocyte...

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Literature Corpus work: 62c04f05-249c-5d99-8bf4-d36c3a21fb41
DOI: 10.64898/2026.01.16.699998

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