Article

Vaccine Elicitation of HIV Broadly Neutralizing Antibodies from Engineered B cells

2020-03-17

Abstract excerpt

HIV broadly neutralizing antibodies (bnAbs) can suppress viremia and protect against infection 1 . However, their elicitation is made difficult by low frequencies of appropriate precursor B cell receptors and the complex maturation pathways required to generate bnAbs from these precursors 2 . Antibody genes can be engineered into B cells for expression as both a functional receptor on cell surfaces and as secret...

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Literature Corpus work: 2e82961d-dbee-50de-ae35-dd15708188f1
DOI: 10.1101/2020.03.17.989699

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