Article

Efficient reprogramming of the heavy-chain CDR3 regions of a human antibody repertoire

2021-04-03

Abstract excerpt

B cells have been engineered ex vivo to express an HIV-1 broadly neutralizing antibody (bNAb). B-cell reprograming may be scientifically and therapeutically useful, but current approaches limit B-cell repertoire diversity and disrupt the organization of the heavy-chain locus. A more diverse and physiologic B-cell repertoire targeting a key HIV-1 epitope could facilitate evaluation of vaccines designed to elicit b...

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Literature Corpus work: 4e846e31-9d62-582f-b2bd-bf917e6d2666
DOI: 10.1101/2021.04.01.437943

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