Article

<i>In vivo</i> production of an anti-HIV antibody from primate hematopoietic cells by non-viral knock-in

2025-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Non-viral gene editing offers a practical alternative to viral delivery for durable biologics production. Clinical trials have shown that adeno-associated virus encoding broadly neutralizing antibodies can protect against HIV, but result in limited, short-lived responses. The development of non-viral gene editing approaches in hematopoietic stem and progenitor cells holds promise for long-term a...

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Literature Corpus work: 8c258d36-df3e-5de6-b05b-a72e4eed407b
DOI: 10.1101/2025.05.02.651933

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