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CRISPR-Mediated Editing of the B Cell Receptor in Primary Human B Cells

1 Feb 2019

Abstract excerpt

Vaccination approaches have generally focused on the antigen rather than the resultant antibodies generated, which differ greatly in quality and function between individuals. The ability to replace the variable regions of the native B cell receptor (BCR) heavy and light chain loci with defined recombined sequences of a preferred monoclonal antibody could enable curative adoptive cell transfer. We report...

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PMID: 30769282
DOI: 10.1016/j.isci.2019.01.032

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