Article
Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion.
Nature communications - 17 Nov 2020
Nahmad Alessio D, Raviv Yuval, Horovitz-Fried Miriam, Sofer Ilan, Akriv Tal, Nataf Daniel, Dotan Iris, Carmi Yaron, Burstein David, Wine Yariv, Benhar Itai, Barzel Adi
Abstract excerpt
HIV viremia can be controlled by chronic antiretroviral therapy. As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) are capable of secreting high antibody titers. Here, we show that, upon immunization of mice, adoptively transferred engineered B cells home to germinal centers (GC) where they predominate over the endogenous...
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