Article

B cells engineered to express pathogen-specific antibodies using CRISPR/Cas9 protect against infection

2019-02-06

Abstract excerpt

Effective vaccines inducing lifelong protection against many important infections such as respiratory syncytial virus (RSV), human immunodeficiency virus (HIV), influenza and Epstein-Barr virus (EBV) are not yet available despite decades of research. As an alternative to a protective vaccine we developed a genetic engineering strategy in which CRISPR/Cas9 was utilized to replace endogenously-encoded antibodies wit...

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Literature Corpus work: 91db7e68-0557-5985-bfd9-31a3f2bfc438
DOI: 10.1101/541979

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