Article

Chimeric organotypic brain slice cultures support the maturation and functional analysis of human iPSC-derived microglia

2025-12-08

Abstract excerpt

<title>Abstract</title> <p>Microglia, the primary myeloid cells of the brain, are crucial for maintaining brain homeostasis and are implicated in various neuropathological processes. Microglial identity and function are determined by their ontogeny and the brain microenvironment. Therefore, model systems that faithfully reproduce mature human microglial molecular and functional phenotypes are crucial for understa...

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Literature Corpus work: c1e3664e-4d81-574d-a0d4-5c58acd290ff
DOI: 10.21203/rs.3.rs-8176878/v1

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