Article

Developing Human Pluripotent Stem Cell-Based Cerebral Organoids with a Controllable Microglia Ratio for Modeling Brain Development and Pathology

2020-10-12

Abstract excerpt

Microglia, as brain-resident macrophages, play critical roles in brain development, homeostasis, and disease. Microglia in animal models cannot accurately model the properties of human microglia due to notable transcriptomic and functional differences between human and other animal microglia. Efficient generation of microglia from human pluripotent stem cells (hPSCs) provides unprecedented opportunities to study t...

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Literature Corpus work: 90841336-6570-59a2-90d9-c902db80ad38
DOI: 10.1101/2020.10.09.331710

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