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Article

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model

27 Feb 2025

Abstract excerpt

Microglia, the resident immune cells of the central nervous system, play a pivotal role in maintaining homeostasis, responding to injury, and modulating neuroinflammation. However, the limitations of rodent models in accurately representing human microglia have posed significant challenges in the study of retinal diseases. PLX5622 was used to eliminate endogenous microglia in mice through oral and intraperitoneal...

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PMID: 40016767
DOI: 10.1186/s12974-025-03393-8

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