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Integration of iPSC-derived microglia into human midbrain organoids enhances microglial maturation and inflammatory signaling

2026-04-07

Abstract excerpt

Microglia are the resident immune cells of the central nervous system and play key roles in the healthy brain during development and adulthood, as well as during neurodegenerative diseases - including Parkinson’s disease (PD). Yet the role of microglia in PD pathogenesis has not been fully elucidated. Limitations of 2D cell culture and animal models in simulating human microglia in the brain parenchyma have contri...

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Literature Corpus work
3b305a4e-4921-5467-b344-12c8a169e7ce
DOI
10.64898/2026.04.06.716748
Open publication

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Integration of iPSC-derived microglia into human midbrain organoids enhances microglial maturation and inflammatory signalingDOI 10.64898/2026.04.06.716748
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