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Article

Human iPSC-Derived Microglia Integrate Into Cerebral Organoids and Assume an In Vivo-Like Phenotype.

The European journal of neuroscience - 1 Nov 2025

Wogram Emile, Sümpelmann Felix, Khalil Andrew, Flamier Anthony, Fu Dongdong, Bell George W, Jaenisch Rudolf

Abstract excerpt

Microglia, the brain-resident macrophages, are critically involved in numerous physiological and pathological brain processes, including neoplasms, epilepsy, and neurodegeneration. However, investigating microglial function is notoriously difficult because they are extremely sensitive to changes in their environment and drastically alter their transcriptional state and morphology once they are isolated from the...

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Identifiers

PMID: 41221983
DOI: 10.1111/ejn.70281
PMCID: PMC12606696

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