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Article

An in vivo neuroimmune organoid model to study human microglia phenotypes.

Cell - 11 May 2023

Schafer Simon T, Mansour Abed AlFatah, Schlachetzki Johannes C M, Pena Monique, Ghassemzadeh Saeed, Mitchell Lisa, Mar Amanda, Quang Daphne, Stumpf Sarah, Ortiz Irene Santisteban, Lana Addison J, Baek Clara, Zaghal Raghad, Glass Christopher K, Nimmerjahn Axel, Gage Fred H

Abstract excerpt

Microglia are specialized brain-resident macrophages that play crucial roles in brain development, homeostasis, and disease. However, until now, the ability to model interactions between the human brain environment and microglia has been severely limited. To overcome these limitations, we developed an in vivo xenotransplantation approach that allows us to study functionally mature human microglia (hMGs) that...

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Identifiers

PMID: 37172564
DOI: 10.1016/j.cell.2023.04.022
PMCID: PMC10284271

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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