Article

Hepatitis C virus replication fitness as a determinant of antiviral therapy outcome

2026-02-04

Abstract excerpt

<h4>Background and Aims</h4> Hepatitis C virus (HCV) infections were previously treated with interferon (IFN) but today direct acting antivirals (DAAs) with cure rates >95% are available. DAA treatment failure is primarily attributed to resistance associated mutations (RAMs), often imposing a fitness cost. Interferon treatment outcome was shown to be associated with the interferon sensitivity determining region (...

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Literature Corpus work: c1c90370-99c2-5874-8ccf-97646b956b99
DOI: 10.64898/2026.02.03.703674

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