Article
Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome.
Journal of viral hepatitis - 1 Feb 2021
Fahnøe Ulrik, Pedersen Martin S, Sølund Christina, Ernst Anja, Krarup Henrik B, Røge Birgit T, Christensen Peer B, Laursen Alex L, Gerstoft Jan, Thielsen Peter, Madsen Lone G, Pedersen Anders G, Schønning Kristian, Weis Nina, Bukh Jens
Abstract excerpt
Direct-acting antivirals (DAAs) have proven highly effective against chronic hepatitis C virus (HCV) infection. However, some patients experience treatment failure, associated with resistance-associated substitutions (RASs). Our aim was to investigate the complete viral coding sequence in hepatitis C patients treated with DAAs to identify RASs and the effects of treatment on the viral population. We selected 22...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.