Article
Viral Fitness, Population Complexity, Host Interactions, and Resistance to Antiviral Agents.
Current topics in microbiology and immunology - 1 Jan 2023
Domingo Esteban, García-Crespo Carlos, Soria María Eugenia, Perales Celia
Abstract excerpt
Fitness of viruses has become a standard parameter to quantify their adaptation to a biological environment. Fitness determinations for RNA viruses (and some highly variable DNA viruses) meet with several uncertainties. Of particular interest are those that arise from mutant spectrum complexity, absence of population equilibrium, and internal interactions among components of a mutant spectrum. Here, concepts,...
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