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Article

Resistance of high fitness hepatitis C virus to lethal mutagenesis.

Virology - 1 Oct 2018

Gallego Isabel, Gregori Josep, Soria María Eugenia, García-Crespo Carlos, García-Álvarez Mónica, Gómez-González Alfonso, Valiergue Rosalie, Gómez Jordi, Esteban Juan Ignacio, Quer Josep, Domingo Esteban, Perales Celia

Abstract excerpt

Viral fitness quantifies the degree of virus adaptation to a given environment. How viral fitness can influence the mutant spectrum complexity of a viral quasispecies subjected to lethal mutagenesis has not been investigated. Here we document that two high fitness hepatitis C virus populations display higher resistance to the mutagenic nucleoside analogues favipiravir and ribavirin than their parental, low...

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Identifiers

PMID: 30107298
DOI: 10.1016/j.virol.2018.07.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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