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Article

Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes.

Journal of virology - 19 Mar 2024

Frericks Nicola, Brown Richard J P, Reinecke Birthe M, Herrmann Maike, Brüggemann Yannick, Todt Daniel, Miskey Csaba, Vondran Florian W R, Steinmann Eike, Pietschmann Thomas, Sheldon Julie

Abstract excerpt

Hepatitis C virus (HCV) infection progresses to chronicity in the majority of infected individuals. Its high intra-host genetic variability enables HCV to evade the continuous selection pressure exerted by the host, contributing to persistent infection. Utilizing a cell culture-adapted HCV population (p100pop) which exhibits increased replicative capacity in various liver cell lines, this study investigated virus...

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Identifiers

PMID: 38319104
DOI: 10.1128/jvi.01921-23
PMCID: PMC10949430

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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