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Article

Replication fitness and NS5B drug sensitivity of diverse hepatitis C virus isolates characterized by using a transient replication assay.

Antimicrobial agents and chemotherapy - 1 May 2005

Ludmerer Steven W, Graham Donald J, Boots Evelyn, Murray Edward M, Simcoe Amy, Markel Eric J, Grobler Jay A, Flores Osvaldo A, Olsen David B, Hazuda Daria J, LaFemina Robert L

Abstract excerpt

The innate genetic variability characteristic of chronic hepatitis C virus (HCV) infection makes drug resistance a concern in the clinical development of HCV inhibitors. To address this, a transient replication assay was developed to evaluate the replication fitness and the drug sensitivity of NS5B sequences isolated from the sera of patients with chronic HCV infection. This novel assay directly compares...

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Identifiers

PMID: 15855532
DOI: 10.1128/AAC.49.5.2059-2069.2005
PMCID: PMC1087645

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Source receipt: pubmed, retrieved 7 Sept 2026.

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