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Article

Hepatitis E virus mutations associated with ribavirin treatment failure result in altered viral fitness and ribavirin sensitivity.

Journal of hepatology - 1 Sept 2016

Debing Yannick, Ramière Christophe, Dallmeier Kai, Piorkowski Géraldine, Trabaud Mary-Anne, Lebossé Fanny, Scholtès Caroline, Roche Magali, Legras-Lachuer Catherine, de Lamballerie Xavier, André Patrice, Neyts Johan

Abstract excerpt

BACKGROUND & AIMS: Ribavirin monotherapy is the preferred treatment for chronic hepatitis E, although occasional treatment failure occurs. We present a patient with chronic hepatitis E experiencing ribavirin treatment failure with a completely resistant phenotype. We aimed to identify viral mutations associated with treatment failure and explore the underlying mechanisms. METHODS: Viral genomes were...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27174035
DOI: 10.1016/j.jhep.2016.05.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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