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Article

A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness.

PLoS pathogens - 1 Aug 2026

Rothhaar Paul, Tubiana Thibault, Förster Colin, Vanegas Arias Gabriel, Arand Tomke, Schäfer Noemi, Ralfs Philipp, Heuss Christian, Piras Antonio, Pichlmair Andreas, Hanoulle Xavier, Bressanelli Stéphane, Lohmann Volker

Abstract excerpt

We previously found that high genome replication fitness of the hepatitis C virus (HCV) was associated with severe disease in immunocompromised patients. Elevated replication fitness was mediated by accumulation of mutations in the replication enhancing domain (ReED) within domain (D) 2 of non-structural protein (NS) 5A. NS5A is a partially unstructured phosphoprotein lacking enzymatic activity but fulfilling a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42555668
DOI: 10.1371/journal.ppat.1014239
PMCID: PMC13472503

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