Article

Highly replicating hepatitis C virus variants emerge in immunosuppressed patients causing severe disease

2025-06-09

Abstract excerpt

<title>Abstract</title> <p>Hepatitis C virus (HCV) exists as a heterogenous quasispecies, but the phenotypic consequences of viral variability are widely unexplored. Here we identified a replication enhancing domain (ReED) in nonstructural protein 5A conferring high replication fitness to clinical isolates. Accumulation of mutations in the ReED mediates high genome replication capacity. In a cohort of liver trans...

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Literature Corpus work: abf6c6bd-8ccf-5eb9-9c83-2f921328d595
DOI: 10.21203/rs.3.rs-6194507/v1

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