Article

A novel dimerization site in non-structural protein 5A of hepatitis C virus regulates viral replication fitness

2026-05-07

Abstract excerpt

We previously found that high genome replication fitness of the hepatitis C virus (HCV) was associated with severe disease in immunocompromised patients. Elevated replication fitness was mediated by accumulation of mutations in the replication enhancing domain (ReED) within domain (D) 2 of non-structural protein (NS) 5A. NS5A is a partially unstructured phosphoprotein lacking enzymatic activity but fulfilling a ke...

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Literature Corpus work: 08a9c73f-bf71-5a95-9e7e-c79bf2c845f7
DOI: 10.64898/2026.05.05.722906

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