Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fitness-associated substitutions following failure of direct-acting antivirals assessed by deep sequencing of full-length hepatitis C virus genomes.

Alimentary pharmacology & therapeutics - 1 Nov 2020

Fourati Slim, Rodriguez Christophe, Soulier Alexandre, Donati Flora, Hamadat Sabah, Poiteau Lila, Demontant Vanessa, Brillet Rozenn, Ahnou Nazim, Gricourt Guillaume, Chevaliez Stéphane, Ahmed-Belkacem Abdelhakim, Pawlotsky Jean-Michel

Abstract excerpt

BACKGROUND: In hepatitis C virus (HCV) infection, treatment failure is generally associated with the selection of resistance-associated substitutions (RAS) conferring reduced susceptibility to direct-acting antiviral (DAA) drugs. Resistant variants continue to replicate after the end of treatment with potential for transmission. This may result from the selection of "fitness-associated substitutions". AIM: To...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug Resistance, Viral
Share to Genetic Fitness

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Hepatitis C, Chronic

Share to Sofosbuvir

Share to Treatment Failure

Share to Viral Nonstructural Proteins

Share to Virus Replication

Source

Identifiers

PMID: 32886807
DOI: 10.1111/apt.16054

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fitness-associated substitutions following failure of direct-acting antivirals assessed by deep sequencing of full-length hepatitis C virus genomes.PMID 32886807Read ↗

Global evolutionary analysis of chronic hepatitis C patients revealed significant effect of baseline viral resistance, including novel non-target sites, for DAA-based treatment and retreatment outcome.Semantic proximity Read ↗

Genetic barrier and variant fitness in hepatitis C as critical parameters for drug resistance development.Semantic proximity Read ↗

Patterns of Resistance-Associated Substitutions in Patients With Chronic HCV Infection Following Treatment With Direct-Acting Antivirals.Semantic proximity Read ↗

Prevalence of Drug Resistance Associated Substitutions in Persons With Chronic Hepatitis C Infection and Virological Failure Following Initial or Re-treatment With Pan-genotypic Direct-Acting Antivirals: A Systematic Review and Meta-analysis.Semantic proximity Read ↗

Hepatitis C virus replication fitness as a determinant of antiviral therapy outcomeSemantic proximity Read ↗

Evolution and persistence of resistance-associated substitutions of hepatitis C virus after direct-acting antiviral treatment failures.Semantic proximity Read ↗

Emergence and Persistence of Resistance-Associated Substitutions in HCV GT3 Patients Failing Direct-Acting AntiviralsSemantic proximity Read ↗

World-wide Prevalence of Substitutions in HCV Genome Associated With Resistance to Direct-Acting Antiviral Agents.Semantic proximity Read ↗

Dynamic evolution of hepatitis C virus resistance-associated substitutions in the absence of antiviral treatment.Semantic proximity Read ↗

Prevalence of HCV resistance-associated substitutions among treatment-failure patients receiving direct-acting antiviral agents.Semantic proximity Read ↗

Amino Acid Substitutions Associated with Treatment Failure for Hepatitis C Virus Infection.Semantic proximity Read ↗

Resistance of high fitness hepatitis C virus to lethal mutagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.