Article

Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis

2025-09-20

Abstract excerpt

<h4>ABSTRACT</h4> Neuronal differentiation requires coordinated gene reprogramming and morphodynamic remodeling. How mechanical forces integrate with nuclear gene programs during neurogenesis remains unresolved. Here, we identify cortical tension as a mechanical barrier that safeguards against premature neuronal differentiation. Deletion of Plexin-B2, a guidance receptor controlling actomyosin contractility, lowe...

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Literature Corpus work: c1bd9cff-77af-594f-bc5d-05a0c8efb0fc
DOI: 10.1101/2025.09.19.677444

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