Article
The distinct role of actin isoforms on mechanosensing-based maturation of hiPSC-derived neurons unveiled by isoform-specific mutations
2026-05-12
Abstract excerpt
Neuronal maturation is governed by the integration of intrinsic programs, such as gene regulation and cellular metabolism, with external mechanical cues. The conversion of mechanical forces into developmental responses (mechanotransduction) requires mechanical coupling of neurons to the extracellular matrix and neighboring cells. This coupling is mediated by the actin cytoskeleton and associated transmembrane prot...
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Identifiers and source
- Literature Corpus work
- 7e5d8171-4012-5b94-a07c-8ea59b7f6b73
- DOI
- 10.64898/2026.05.11.724094