Article

Astrocytic Regulation of aberrant perineuronal net formation in <i>Mecp2</i> -null Neocortex

2025-08-13

Abstract excerpt

Rett syndrome (RTT), caused by mutations in MECP2 , is a complex neurological disorder characterized by myriad physiological disruptions, including early closure of the critical period of developmental plasticity and precocious formation of perineuronal nets (PNNs). PNNs are lattice-like substructures of extracellular matrix (ECM) that enwrap specific subpopulations of neurons. PNNs are essential in the modulatio...

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Literature Corpus work: 9e56684c-9987-5c98-866e-4edb1587c98d
DOI: 10.1101/2025.08.13.670146

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