Article

Lamin B1 physically regulates neuronal migration by modulating nuclear deformability in the developing cortex

2025-10-22

Abstract excerpt

Neuronal migration is a vital process that positions billions of neurons to create a functional brain. To navigate the constrained microenvironments within the cortex, precise control over the nuclear mechanics in migrating neurons is indispensable. Here, we show that Lamin B1 (LB1) regulates neuronal migration by modulating nuclear deformability. Excess LB1 in neurons halted migration without altering laminar ide...

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Identifiers and source

Literature Corpus work: 8606fd35-d7a1-52e4-9632-c2510abad344
DOI: 10.1101/2025.10.22.683830

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