Article

MeCP2 binding and genome–lamina reorganization precede long gene activation during mouse corticogenesis

2025-09-01

Abstract excerpt

During corticogenesis, neural gene expression is tightly coordinated by chromatin and epigenetic changes, whose misregulation can lead to neurodevelopmental disorders 1–4 . The role of spatial genome organization—particularly interactions with the nuclear lamina—during these developmental programs remains poorly understood. Here, we combined in utero electroporation with scDam&T-seq to jointly profile genome–lami...

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Literature Corpus work: fc3d220a-8b13-5e8e-a0d1-70fb028b1e01
DOI: 10.1101/2025.09.01.673434

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