Article

Post-translational Tuning of Human Cortical Progenitor Neuronal Output

2025-10-27

Abstract excerpt

<h4>ABSTRACT</h4> The striking expansion of the human neocortex is driven by the ability of radial glial cells (RGCs) to prolong neurogenesis without exhausting their progenitor pool, thereby producing more neurons, particularly in the upper layers. The mechanisms underlying enhanced human neurogenic output remain unresolved. We hypothesized that post-translational modification of conserved proteins could provide...

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Literature Corpus work: 3e9e410a-012f-584f-8771-71aeb089f455
DOI: 10.1101/2025.10.27.684791

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