Article

Cortical tension as a mechanical barrier to safeguard against premature differentiation during neurogenesis

2025-10-31

Abstract excerpt

<title>Abstract</title> <p>Neuronal differentiation requires coordinated gene reprogramming and morphodynamic remodeling. How mechanical forces integrate with nuclear gene programs during neurogenesis remains unresolved. Here, we identify cortical tension as a mechanical barrier that safeguards against premature neuronal differentiation. Deletion of Plexin-B2, a guidance receptor controlling actomyosin contractil...

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Literature Corpus work: 3bf60f40-e829-500d-9434-814cdd9c9ff6
DOI: 10.21203/rs.3.rs-7725502/v1

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