Article

Human basal radial glia morphotypes are transcriptionally distinct and exhibit different cell fate determination

2026-01-22

Abstract excerpt

<h4>Summary</h4> Basal radial glia (bRG) are key neural progenitors driving human neocortical expansion. They exhibit remarkable morphological heterogeneity, yet the stability and functional significance of their distinct morphotypes remains unclear. Using human cortical brain organoids combined with long-term live imaging and morphology-resolved spatial transcriptomics (CellShape-seq), we show that bRG morphotyp...

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Literature Corpus work: 846548c1-59fc-54a6-93a9-ab8fc4018649
DOI: 10.64898/2026.01.22.701090

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