Article

<i>Let-7</i> restrains an oncogenic circuit in AT2 cells to prevent fibrogenic cell intermediates in pulmonary fibrosis

2024-05-24

Abstract excerpt

Analysis of lung alveolar type 2 (AT2) progenitor stem cells has highlighted fundamental mechanisms that direct their differentiation into alveolar type 1 cells (AT1s) in lung repair and disease. However, microRNA (miRNA) mediated post-transcriptional mechanisms which govern this nexus remain understudied. We show here that the let-7 miRNA family serves a homeostatic role in governance of AT2 quiescence, specific...

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Literature Corpus work: c1a7795c-ddef-5467-af57-e1c3c6ae2a97
DOI: 10.1101/2024.05.22.595205

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