Article

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF)

2026-06-10

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a fatal, age-associated lung disease in which alveolar type II (AT2) cells lose regenerative capacity and can adopt aberrant basal-like fates that promote fibrosis. Using 3D organoid co-cultures with primary human fibroblasts, we find that healthy human AT2 cell trans-differentiation into KRT5+/KRT17+ basal cells increases progressively with age, while differentiation into RA...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f08ec09-d08d-55b7-b619-b25c1aaf93aa
DOI: 10.64898/2026.06.09.731212

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenetic de-repression of basal cell metaplasia in aging AT2 cells is a risk factor for idiopathic pulmonary fibrosis (IPF)DOI 10.64898/2026.06.09.731212Read

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungsSemantic proximity Read

Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human LungsSemantic proximity Read

Autocrine TGF-β-positive feedback in profibrotic AT2-lineage cells plays a crucial role in non-inflammatory lung fibrogenesisSemantic proximity Read

Alveolar epithelial cell plasticity and injury memory in human pulmonary fibrosisSemantic proximity Read

Cross-species integration of single-cell RNA-seq resolved alveolar-epithelial transitional states in idiopathic pulmonary fibrosisSemantic proximity Read

Cellular profiling identifies an early profibrotic alveolar type 2 cell signature in lung fibrosisSemantic proximity Read

Single-cell RNA-seq reveals ectopic and aberrant lung-resident cell populations in idiopathic pulmonary fibrosisSemantic proximity Read

Pathogenic Mechanisms Underlying Idiopathic Pulmonary FibrosisSemantic proximity Read

Lineage-tracing of <i>Acta2</i> + cells in aged mice during lung fibrosis formation and resolution supports the lipofibroblast to myofibroblast reversible switchSemantic proximity Read

Alveolar Epithelial Cell Loss of the Mitochondrial Regulator TFAM Drives Progressive Lung FibrosisSemantic proximity Read

AP-1 mediated chromatin changes govern alveolar type 2 cell transition in lung injury-repairSemantic proximity Read

Progressive lung fibrosis: reprogramming a genetically vulnerable bronchoalveolar epitheliumSemantic proximity Read