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Organoid modeling reveals the tumorigenic potential of the alveolar progenitor cell state

10 Feb 2025

Abstract excerpt

Cancers display cellular, genetic and epigenetic heterogeneity, complicating disease modeling. Multiple cell states defined by gene expression have been described in lung adenocarcinoma (LUAD). However, the functional contributions of cell state and the regulatory programs that control chromatin and gene expression in the early stages of tumor initiation are not well understood. Using single-cell RNA and ATAC...

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PMID: 39930268
DOI: 10.1038/s44318-025-00376-6

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