Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs

18 Apr 2024

Abstract excerpt

Aging poses a global public health challenge, which is linked to the rise of age-related lung diseases. The precise understanding of the molecular and genetic changes in the aging lung that elevate the risk of acute and chronic lung diseases remains incomplete. Alveolar type II (AT2) cells are stem cells that maintain epithelial homeostasis and repair the lung after injury. AT2 progenitor function decreases with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital Diaphragmatic Hernia Studies
Share to Epigenetics and DNA Methylation
Share to Neonatal Respiratory Health Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38635761
DOI: 10.1165/rcmb.2023-0363oc

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human LungsPMID 38635761Read ↗

A transcriptional cell atlas identifies the decline in the AT2 niche in aged human lungsSemantic proximity Read ↗

Reciprocal interactions between alveolar progenitor dysfunction and aging promote lung fibrosisSemantic proximity Read ↗

A Multi-omic Analysis of the Human Lung Reveals Distinct Cell Specific Aging and Senescence Molecular ProgramsSemantic proximity Read ↗

A genomic perspective of the aging human and mouse lung with a focus on immune response and cellular senescenceSemantic proximity Read ↗

Heterogeneous groups of alveolar type II cells in lung homeostasis and repairSemantic proximity Read ↗

An integrated single-cell atlas of human lung across the lifespanSemantic proximity Read ↗

An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomicsSemantic proximity Read ↗

Single Cell Transcriptomics of Fibrotic Lungs Unveils Aging-associated Alterations in Endothelial and Epithelial Cell RegenerationSemantic proximity Read ↗

Single-cell atlas of human lung aging identifies cell type dyssynchrony and increased transcriptional entropy.Semantic proximity Read ↗

Single-Cell Transcriptomics Identifies Dysregulated Metabolic Programs of Aging Alveolar Progenitor Cells in Lung FibrosisSemantic proximity Read ↗

Single cell RNA sequencing unravels mechanisms underlying senescence-like phenotypes of alveolar macrophagesSemantic proximity Read ↗

Deciphering the age-dependent changes of pulmonary fibroblasts in mice by single-cell transcriptomicsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.