Article

G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation

2020-04-20

Abstract excerpt

Lung development, integrity and repair rely on precise Wnt signaling, which is corrupted in diverse diseases, including cancer. Here, we discover that G9a methyltransferase regulates Wnt signaling in the lung by controlling the transcriptional activity of chromatin-bound β-catenin, through a non-histone substrate. Inhibition of G9a induces transcriptional, morphologic, and molecular changes consistent with alveola...

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Literature Corpus work: 8a6f19e1-4b95-5b6e-9787-dab785280b78
DOI: 10.1101/2020.04.20.050328

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G9a methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagationDOI 10.1101/2020.04.20.050328Read

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