Article

Primate lineage specification requires suppression of Alu hyperediting

2026-01-15

Abstract excerpt

<h4>ABSTRACT</h4> Understanding human specific mechanisms of cell fate control is essential for advancing developmental biology and regenerative medicine. Here, we identify the ILF2/3 complex as a critical regulator of primate cell fate transitions. Using genetically and epigenetically engineered gastruloids and adult stem cells, we show that ILF2/3 is required for gastrulation in primates but not mice, and for d...

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Literature Corpus work: 80ee8201-7bbc-5f2f-9502-722f68527731
DOI: 10.64898/2026.01.14.699349

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