Article

In vivo interrogation of transcriptional and epigenetic regulators of lung epithelial regeneration

2026-03-17

Abstract excerpt

Effective alveolar repair after viral lung injury requires precise coordination of alveolar type 2 cell (AT2) proliferation and differentiation to restore lung function. To uncover causal regulators of this process in the native tissue environment, we developed SAGE (Stable Adeno-Associated Virus Genomic IntEgration), an engineered AAV system that enables high-throughput in vivo genetic interrogation. SAGE support...

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Literature Corpus work: a701f6dc-459e-5a8d-9c60-70ea63aed204
DOI: 10.64898/2026.03.13.711474

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